Simultaneous LC-ESI-MS/MS Quantification of Levosimendan and Its Metabolites for Therapeutic Drug Monitoring of Cardiac Surgery Patients

Levosimendan is used in severe chronic cardiac insufficiency, also within the peri-operative setting. Real-life pharmacokinetic data in surgical patients is lacking, making therapeutic drug monitoring (TDM) of levosimendan, its pharmacologically active metabolite OR-1896, and its intermediate OR-185...

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Detalles Bibliográficos
Autores principales: Kipka, Hannah, Tomasi, Roland, Hübner, Max, Liebchen, Uwe, Hagl, Christian, Wanner, Klaus T., Mannell, Hanna, Höfner, Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319272/
https://www.ncbi.nlm.nih.gov/pubmed/35890349
http://dx.doi.org/10.3390/pharmaceutics14071454

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319272/
https://www.ncbi.nlm.nih.gov/pubmed/35890349
http://dx.doi.org/10.3390/pharmaceutics14071454

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