The N-Methyl-D-Aspartate Receptor Blocker REL-1017 (Esmethadone) Reduces Calcium Influx Induced by Glutamate, Quinolinic Acid, and Gentamicin

REL-1017 (esmethadone) is a novel N-methyl-D-aspartate receptor (NMDAR) antagonist and promising rapid antidepressant candidate. Using fluorometric imaging plate reader (FLIPR) assays, we studied the effects of quinolinic acid (QA) and gentamicin, with or without L-glutamate and REL-1017, on intrace...

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Detalles Bibliográficos
Autores principales: Bettini, Ezio, De Martin, Sara, Mattarei, Andrea, Pappagallo, Marco, Stahl, Stephen M., Bifari, Francesco, Inturrisi, Charles E., Folli, Franco, Traversa, Sergio, Manfredi, Paolo L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319291/
https://www.ncbi.nlm.nih.gov/pubmed/35890179
http://dx.doi.org/10.3390/ph15070882

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319291/
https://www.ncbi.nlm.nih.gov/pubmed/35890179
http://dx.doi.org/10.3390/ph15070882

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