Binding Studies and Lead Generation of Pteridin-7(8H)-one Derivatives Targeting FLT3

Ligand modification by substituting chemical groups within the binding pocket is a popular strategy for kinase drug development. In this study, a series of pteridin-7(8H)-one derivatives targeting wild-type FMS-like tyrosine kinase-3 (FLT3) and its D835Y mutant (FL3(D835Y)) were studied using a comb...

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Detalles Bibliográficos
Autores principales: Ghosh, Suparna, Cho, Seung Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319409/
https://www.ncbi.nlm.nih.gov/pubmed/35887060
http://dx.doi.org/10.3390/ijms23147696

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319409/
https://www.ncbi.nlm.nih.gov/pubmed/35887060
http://dx.doi.org/10.3390/ijms23147696

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