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Binding Studies and Lead Generation of Pteridin-7(8H)-one Derivatives Targeting FLT3
Ligand modification by substituting chemical groups within the binding pocket is a popular strategy for kinase drug development. In this study, a series of pteridin-7(8H)-one derivatives targeting wild-type FMS-like tyrosine kinase-3 (FLT3) and its D835Y mutant (FL3(D835Y)) were studied using a comb...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319409/ https://www.ncbi.nlm.nih.gov/pubmed/35887060 http://dx.doi.org/10.3390/ijms23147696 |