The Usefulness of In Vitro Percutaneous Absorption Experiments Applying the Infinite Dose Technique to Predict In Vivo Plasma Levels: Comparison of Model-Predicted and Observed Plasma Concentrations of Nortriptyline in Rats

The aims of this study were to evaluate the feasibility of a nortriptyline (NT) formulation for transdermal administration and to assess the usefulness of an estimated kinetic parameter (k(out)) using the in vitro infinite dose technique to predict in vivo plasma levels when used in combination with...

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Detalles Bibliográficos
Autores principales: Usach, Iris, Di Marco, Sara, Díez, Octavio, Alós, Manuel, Peris, José-Esteban
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319520/
https://www.ncbi.nlm.nih.gov/pubmed/35890351
http://dx.doi.org/10.3390/pharmaceutics14071457

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319520/
https://www.ncbi.nlm.nih.gov/pubmed/35890351
http://dx.doi.org/10.3390/pharmaceutics14071457

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