Relative Nuclease Resistance of a DNA Aptamer Covalently Conjugated to a Target Protein

A major obstacle to the therapeutic application of an aptamer is its susceptibility to nuclease digestion. Here, we confirmed the acquisition of relative nuclease resistance of a DNA-type thrombin binding aptamer with a warhead (TBA(3)) by covalent binding to a target protein in the presence of seru...

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Detalles Bibliográficos
Autores principales: Tabuchi, Yudai, Yang, Jay, Taki, Masumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319527/
https://www.ncbi.nlm.nih.gov/pubmed/35887130
http://dx.doi.org/10.3390/ijms23147778

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319527/
https://www.ncbi.nlm.nih.gov/pubmed/35887130
http://dx.doi.org/10.3390/ijms23147778

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