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Relative Nuclease Resistance of a DNA Aptamer Covalently Conjugated to a Target Protein
A major obstacle to the therapeutic application of an aptamer is its susceptibility to nuclease digestion. Here, we confirmed the acquisition of relative nuclease resistance of a DNA-type thrombin binding aptamer with a warhead (TBA(3)) by covalent binding to a target protein in the presence of seru...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319527/ https://www.ncbi.nlm.nih.gov/pubmed/35887130 http://dx.doi.org/10.3390/ijms23147778 |