Synthesis and Biological Evaluation of Imadazo[1,2-a]pyrazines as Anticancer and Antiviral Agents through Inhibition of CDK9 and Human Coronavirus

In this work, novel imadazo[1,2-a]pyrazine derivatives were synthesized and evaluated as CDK9 inhibitors. The results of CDK9 assay showed that the derivatives with pyridin-4-yl in position 2 and benzyl in position 3 of imadazo[1,2-a]pyrazine 3c displayed the most potent CDK9 inhibitory activity wit...

Descripción completa

Detalles Bibliográficos
Autores principales: Alsfouk, Aisha A., Alshibl, Hanan M., Alsfouk, Bshra A., Altwaijry, Najla A., Al-Abdullah, Ebtehal S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319549/
https://www.ncbi.nlm.nih.gov/pubmed/35890157
http://dx.doi.org/10.3390/ph15070859

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319549/
https://www.ncbi.nlm.nih.gov/pubmed/35890157
http://dx.doi.org/10.3390/ph15070859

Ejemplares similares