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Synthesis and Biological Evaluation of Imadazo[1,2-a]pyrazines as Anticancer and Antiviral Agents through Inhibition of CDK9 and Human Coronavirus

In this work, novel imadazo[1,2-a]pyrazine derivatives were synthesized and evaluated as CDK9 inhibitors. The results of CDK9 assay showed that the derivatives with pyridin-4-yl in position 2 and benzyl in position 3 of imadazo[1,2-a]pyrazine 3c displayed the most potent CDK9 inhibitory activity wit...

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Detalles Bibliográficos
Autores principales:	Alsfouk, Aisha A., Alshibl, Hanan M., Alsfouk, Bshra A., Altwaijry, Najla A., Al-Abdullah, Ebtehal S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319549/ https://www.ncbi.nlm.nih.gov/pubmed/35890157 http://dx.doi.org/10.3390/ph15070859

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