Cargando…
The Protective Effect of Edaravone on TDP-43 Plus Oxidative Stress-Induced Neurotoxicity in Neuronal Cells: Analysis of Its Neuroprotective Mechanisms Using RNA Sequencing
Edaravone is a free-radical scavenger drug that was recently approved for the treatment of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease. A pathological hallmark of ALS is the accumulation of ubiquitinated or phosphorylated aggregates of the 43-kDa transactive response DNA binding...
Autores principales: | Soejima-Kusunoki, Aki, Okada, Kinya, Saito, Ryuta, Watabe, Kazuhiko |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319738/ https://www.ncbi.nlm.nih.gov/pubmed/35890141 http://dx.doi.org/10.3390/ph15070842 |
Ejemplares similares
-
TDP-43 causes neurotoxicity and cytoskeletal dysfunction in primary cortical neurons
por: Baskaran, Pranetha, et al.
Publicado: (2018) -
Protective Effect of Edaravone on Glutamate-Induced Neurotoxicity in Spiral Ganglion Neurons
por: Bai, Xiaohui, et al.
Publicado: (2016) -
Endolysosomal pathway activity protects cells from neurotoxic TDP-43
por: Leibiger, Christine, et al.
Publicado: (2018) -
Retraction: TDP-43 causes neurotoxicity and cytoskeletal dysfunction in primary cortical neurons
Publicado: (2021) -
Identification of Genetic Modifiers of TDP-43 Neurotoxicity in Drosophila
por: Zhan, Lihong, et al.
Publicado: (2013)