Specific Targeting of Antiapoptotic Bcl-2 Proteins as a Radiosensitizing Approach in Solid Tumors

Avoidance of therapy-induced apoptosis is a hallmark of acquired resistance towards radiotherapy. Thus, breaking resistance still challenges modern cancer therapy. The Bcl-2 protein family is known for its regulatory role in apoptosis signaling, making Bcl-2, Mcl-1 and Bcl-x(L) promising targets. Th...

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Detalles Bibliográficos
Autores principales: Sobol, Benjamin, Azzam Nieto, Osama, Eberlein, Emily Lara, Scherr, Anna-Lena, Ismail, Lars, Kessler, Annika, Nader, Luisa, Schwab, Maximilian, Hoffmeister, Paula, Schmitt, Nathalie, Jäger, Dirk, Welte, Stefan, Seidensaal, Katharina, Christopoulos, Petros, Heilig, Christoph, Kriegsmann, Katharina, Fröhling, Stefan, Kriegsmann, Mark, Hess, Jochen, Köhler, Bruno Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319836/
https://www.ncbi.nlm.nih.gov/pubmed/35887198
http://dx.doi.org/10.3390/ijms23147850

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319836/
https://www.ncbi.nlm.nih.gov/pubmed/35887198
http://dx.doi.org/10.3390/ijms23147850

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