Cargando…

Specific Targeting of Antiapoptotic Bcl-2 Proteins as a Radiosensitizing Approach in Solid Tumors

Avoidance of therapy-induced apoptosis is a hallmark of acquired resistance towards radiotherapy. Thus, breaking resistance still challenges modern cancer therapy. The Bcl-2 protein family is known for its regulatory role in apoptosis signaling, making Bcl-2, Mcl-1 and Bcl-x(L) promising targets. Th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sobol, Benjamin, Azzam Nieto, Osama, Eberlein, Emily Lara, Scherr, Anna-Lena, Ismail, Lars, Kessler, Annika, Nader, Luisa, Schwab, Maximilian, Hoffmeister, Paula, Schmitt, Nathalie, Jäger, Dirk, Welte, Stefan, Seidensaal, Katharina, Christopoulos, Petros, Heilig, Christoph, Kriegsmann, Katharina, Fröhling, Stefan, Kriegsmann, Mark, Hess, Jochen, Köhler, Bruno Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319836/ https://www.ncbi.nlm.nih.gov/pubmed/35887198 http://dx.doi.org/10.3390/ijms23147850

Ejemplares similares

Beyond Cell Death – Antiapoptotic Bcl-2 Proteins Regulate Migration and Invasion of Colorectal Cancer Cells In Vitro
por: Koehler, Bruno Christian, et al.
Publicado: (2013)

Prognostic Impact of PD-L1 Expression in pN1 NSCLC: A Retrospective Single-Center Analysis
por: Eichhorn, Florian, et al.
Publicado: (2021)

Identification of Gastritis Subtypes by Convolutional Neuronal Networks on Histological Images of Antrum and Corpus Biopsies
por: Steinbuss, Georg, et al.
Publicado: (2020)

Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) including Variant Analysis by Mass Spectrometry in Placental Tissue
por: Wierz, Marina, et al.
Publicado: (2022)

Imaging Mass Spectrometry-Based Proteomic Analysis to Differentiate Melanocytic Nevi and Malignant Melanoma
por: Casadonte, Rita, et al.
Publicado: (2021)

Imaging Mass Spectrometry for the Classification of Melanoma Based on BRAF/NRAS Mutational Status
por: Casadonte, Rita, et al.
Publicado: (2023)

Biological injection therapy with leukocyte-poor platelet-rich plasma induces cellular alterations, enhancement of lubricin, and inflammatory downregulation in vivo in human knees: A controlled, prospective human clinical trial based on mass spectrometry imaging analysis
por: Baltzer, Axel W., et al.
Publicado: (2023)

Stem Cell Mobilization, Collection, and Processing
por: Kriegsmann, Katharina, et al.
Publicado: (2023)

Major clinical benefit from adjuvant chemotherapy for stage II–III non-small cell lung cancer patients aged 75 years or older: a propensity score-matched analysis
por: Blasi, Miriam, et al.
Publicado: (2022)

Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) by Mass Spectrometry
por: Wandernoth, Petra, et al.
Publicado: (2020)

Mass Spectrometry Imaging for Reliable and Fast Classification of Non-Small Cell Lung Cancer Subtypes
por: Kriegsmann, Mark, et al.
Publicado: (2020)

A Comparison of Different Sample Processing Protocols for MALDI Imaging Mass Spectrometry Analysis of Formalin-Fixed Multiple Myeloma Cells
por: Casadonte, Rita, et al.
Publicado: (2023)

Immunohistological Expression of SOX-10 in Triple-Negative Breast Cancer: A Descriptive Analysis of 113 Samples
por: Kriegsmann, Katharina, et al.
Publicado: (2020)

Accuracy and Reliability of Internet Resources for Information on Monoclonal Gammopathy of Undetermined Significance—What Information Is out There for Our Patients?
por: Kreutzer, Emma Pauline, et al.
Publicado: (2021)

Deep Learning in Pancreatic Tissue: Identification of Anatomical Structures, Pancreatic Intraepithelial Neoplasia, and Ductal Adenocarcinoma
por: Kriegsmann, Mark, et al.
Publicado: (2021)

Role of Synaptophysin, Chromogranin and CD56 in adenocarcinoma and squamous cell carcinoma of the lung lacking morphological features of neuroendocrine differentiation: a retrospective large-scale study on 1170 tissue samples
por: Kriegsmann, Katharina, et al.
Publicado: (2021)

Implementation of deep learning in liver pathology optimizes diagnosis of benign lesions and adenocarcinoma metastasis
por: Kriegsmann, Mark, et al.
Publicado: (2023)

Deep learning for the detection of anatomical tissue structures and neoplasms of the skin on scanned histopathological tissue sections
por: Kriegsmann, Katharina, et al.
Publicado: (2022)

Corrigendum: Deep learning for the detection of anatomical tissue structures and neoplasms of the skin on scanned histopathological tissue sections
por: Kriegsmann, Katharina, et al.
Publicado: (2023)

Inhibition of Antiapoptotic BCL-XL, BCL-2, and MCL-1 Proteins by Small Molecule Mimetics
por: Dalafave, D.S., et al.
Publicado: (2010)

Cellular Senescence in Normal Mammary Gland and Breast Cancer. Implications for Cancer Therapy
por: Sirinian, Chaido, et al.
Publicado: (2022)

Histological and molecular plasticity of ALK-positive non-small-cell lung cancer under targeted therapy: a case report
por: Ball, Markus, et al.
Publicado: (2022)

Synoviale Veränderungen bei Erkrankungen des rheumatologischen Formenkreises und Differenzialdiagnosen
por: Kriegsmann, Mark, et al.
Publicado: (2022)

Deep Learning for the Classification of Non-Hodgkin Lymphoma on Histopathological Images
por: Steinbuss, Georg, et al.
Publicado: (2021)

Cell-based immunotherapy approaches for multiple myeloma
por: Kriegsmann, Katharina, et al.
Publicado: (2018)

Multimodal Lung Cancer Subtyping Using Deep Learning Neural Networks on Whole Slide Tissue Images and MALDI MSI
por: Janßen, Charlotte, et al.
Publicado: (2022)

Differential Glycosite Profiling—A Versatile Method to Compare Membrane Glycoproteomes
por: Michalak, Malwina, et al.
Publicado: (2021)

An antiapoptotic Bcl-2 family protein index predicts the response of leukaemic cells to the pan-Bcl-2 inhibitor S1
por: Zhang, Z, et al.
Publicado: (2013)

PLK1 as a cooperating partner for BCL2-mediated antiapoptotic program in leukemia
por: Shah, Kinjal, et al.
Publicado: (2023)

Early Development of Ubiquitous Acanthocytosis and Extravascular Hemolysis in Lung Cancer Patients Receiving Alectinib
por: Kunz, Julia, et al.
Publicado: (2022)

Site‐to‐Site Reproducibility and Spatial Resolution in MALDI–MSI of Peptides from Formalin‐Fixed Paraffin‐Embedded Samples
por: Ly, Alice, et al.
Publicado: (2019)

Simultaneous siRNA-mediated knockdown of antiapoptotic BCL2, Bcl-xL, XIAP and survivin in bladder cancer cells
por: KUNZE, DOREEN, et al.
Publicado: (2012)

Molecular Docking Study of Naturally Derived Flavonoids with Antiapoptotic BCL-2 and BCL-XL Proteins toward Ovarian Cancer Treatment
por: Abd Ghani, Mohd Faiz, et al.
Publicado: (2020)

Low-dose peripheral blood stem cell graft after high-dose chemotherapy - an evaluation of hematopoietic reconstitution
por: Sauer, Sandra, et al.
Publicado: (2020)

miR-326 Targets Antiapoptotic Bcl-xL and Mediates Apoptosis in Human Platelets
por: Yu, Shifang, et al.
Publicado: (2015)

Competition Between Phenothiazines and BH3 Peptide for the Binding Site of the Antiapoptotic BCL-2 Protein
por: do Carmo, Aline Lagoeiro, et al.
Publicado: (2020)

Regulation of the antiapoptotic protein cFLIP by the glucocorticoid Dexamethasone in ALL cells
por: Kleinesudeik, Lara, et al.
Publicado: (2018)

Expression of HMB45, MelanA and SOX10 is rare in non-small cell lung cancer
por: Kriegsmann, Mark, et al.
Publicado: (2018)

A gene expression signature associated with B cells predicts benefit from immune checkpoint blockade in lung adenocarcinoma
por: Budczies, Jan, et al.
Publicado: (2021)

Detection of KRAS, NRAS and BRAF by mass spectrometry - a sensitive, reliable, fast and cost-effective technique
por: Kriegsmann, Mark, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_qigpn3j43g100rorpg0mnn3eal