Design, Synthesis and Evaluation of Novel Phorbazole C Derivatives as MNK Inhibitors through Virtual High-Throughput Screening

MNKs (mitogen-activated protein kinase-interacting protein kinases) phosphorylate eIF4E at Ser209 to control the translation of certain mRNAs and regulate the process of cell proliferation, cell migration and invasion, etc. Development of MNK inhibitors would be an effective treatment for related di...

Descripción completa

Detalles Bibliográficos
Autores principales: Jin, Xin, Li, Maowei, Qiu, Tingting, Yu, Rilei, Jiang, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319845/
https://www.ncbi.nlm.nih.gov/pubmed/35877722
http://dx.doi.org/10.3390/md20070429

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319845/
https://www.ncbi.nlm.nih.gov/pubmed/35877722
http://dx.doi.org/10.3390/md20070429

Ejemplares similares