Recent Advances in Improving Gene-Editing Specificity through CRISPR–Cas9 Nuclease Engineering

CRISPR–Cas9 is the state-of-the-art programmable genome-editing tool widely used in many areas. For safe therapeutic applications in clinical medicine, its off-target effect must be dramatically minimized. In recent years, extensive studies have been conducted to improve the gene-editing specificity...

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Detalles Bibliográficos
Autores principales: Huang, Xiaoqiang, Yang, Dongshan, Zhang, Jifeng, Xu, Jie, Chen, Y. Eugene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319960/
https://www.ncbi.nlm.nih.gov/pubmed/35883629
http://dx.doi.org/10.3390/cells11142186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319960/
https://www.ncbi.nlm.nih.gov/pubmed/35883629
http://dx.doi.org/10.3390/cells11142186

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