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Recent Advances in Improving Gene-Editing Specificity through CRISPR–Cas9 Nuclease Engineering
CRISPR–Cas9 is the state-of-the-art programmable genome-editing tool widely used in many areas. For safe therapeutic applications in clinical medicine, its off-target effect must be dramatically minimized. In recent years, extensive studies have been conducted to improve the gene-editing specificity...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319960/ https://www.ncbi.nlm.nih.gov/pubmed/35883629 http://dx.doi.org/10.3390/cells11142186 |