Cargando…

Novel Design of RNA Aptamers as Cancer Inhibitors and Diagnosis Targeting the Tyrosine Kinase Domain of the NT-3 Growth Factor Receptor Using a Computational Sequence-Based Approach

Aptamers, the nucleic acid analogs of antibodies, bind to their target molecules with remarkable specificity and sensitivity, making them promising diagnostic and therapeutic tools. The systematic evolution of ligands by exponential enrichment (SELEX) is time-consuming and expensive. However, regard...

Descripción completa

Detalles Bibliográficos
Autores principales:	Muhammad, Ashraf M., Zari, Ali, Alsubhi, Nouf H., Al-Zahrani, Maryam H., Alghamdi, Rana Abdullah, Labib, Mai M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320020/ https://www.ncbi.nlm.nih.gov/pubmed/35889390 http://dx.doi.org/10.3390/molecules27144518

Ejemplares similares

The Regioselective Conjugation of the 15-nt Thrombin Aptamer with an Optimized Tripeptide Sequence Greatly Increases the Anticoagulant Activity of the Aptamer
por: Varizhuk, Irina V., et al.
Publicado: (2023)

Neutralizing Aptamers from Whole-Cell SELEX Inhibit the RET Receptor Tyrosine Kinase
por: Cerchia, Laura, et al.
Publicado: (2005)

Cell Surface Labeling and Detection of Protein Tyrosine Kinase 7 via Covalent Aptamers
por: Albright, Savannah, et al.
Publicado: (2023)

Integrated bioinformatics analyses identifying key transcriptomes correlated with prognosis and immune infiltrations in lung squamous cell carcinoma
por: Alghamdi, Rana A., et al.
Publicado: (2023)

Identification of key claudin genes associated with survival prognosis and diagnosis in colon cancer through integrated bioinformatic analysis
por: Alghamdi, Rana A., et al.
Publicado: (2023)

Retraction: Neutralizing Aptamers from Whole-Cell SELEX Inhibit the RET Receptor Tyrosine Kinase
por: Cerchia, Laura, et al.
Publicado: (2015)

Aptamer‐targeted DNA nanostructures with doxorubicin to treat protein tyrosine kinase 7‐positive tumours
por: Liu, Mengting, et al.
Publicado: (2018)

Autoinhibition of the Ron receptor tyrosine kinase by the juxtamembrane domain
por: Wang, Xin, et al.
Publicado: (2014)

Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1
por: Kan, Yagmur, et al.
Publicado: (2023)

Targeting Ephrin Receptor Tyrosine Kinase A2 with a Selective Aptamer for Glioblastoma Stem Cells
por: Affinito, Alessandra, et al.
Publicado: (2020)

Recent Advances in the Role of Discoidin Domain Receptor Tyrosine Kinase 1 and Discoidin Domain Receptor Tyrosine Kinase 2 in Breast and Ovarian Cancer
por: Chen, Li, et al.
Publicado: (2021)

Mutations in the MET tyrosine kinase domain and resistance to tyrosine kinase inhibitors in non-small-cell lung cancer
por: Yao, Yu, et al.
Publicado: (2023)

One-Step Photochemical Immobilization of Aptamer on Graphene for Label-Free Detection of NT-proBNP
por: Nekrasov, Nikita, et al.
Publicado: (2022)

Erlotinib binds both inactive and active conformations of the EGFR tyrosine kinase domain
por: Park, Jin H., et al.
Publicado: (2012)

The Tyrosine Kinase Csk Dimerizes through Its SH3 Domain
por: Levinson, Nicholas M., et al.
Publicado: (2009)

SH2 domains: modulators of nonreceptor tyrosine kinase activity
por: Filippakopoulos, Panagis, et al.
Publicado: (2009)

A Src-Like Inactive Conformation in the Abl Tyrosine Kinase Domain
por: Levinson, Nicholas M, et al.
Publicado: (2006)

Effects of Nt-truncation and coexpression of isolated Nt domains on the membrane trafficking of electroneutral Na(+)/HCO(3)(–) cotransporters
por: Wang, Deng-Ke, et al.
Publicado: (2015)

Structural and Spectroscopic Analysis of the Kinase Inhibitor Bosutinib and an Isomer of Bosutinib Binding to the Abl Tyrosine Kinase Domain
por: Levinson, Nicholas M., et al.
Publicado: (2012)

Multi-carbon dots and aptamer based signal amplification ratiometric fluorescence probe for protein tyrosine kinase 7 detection
por: Ma, Yunsu, et al.
Publicado: (2021)

FGFR1 tyrosine kinase domain duplication in pilocytic astrocytoma with anaplasia
por: Ballester, Leomar Y., et al.
Publicado: (2018)

Pulmonary hypertension with dasatinib and other tyrosine kinase inhibitors
por: El-Dabh, Ashraf, et al.
Publicado: (2019)

Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain
por: Estevam, Gabriella O., et al.
Publicado: (2023)

Targeting c‐met receptor tyrosine kinase by the DNA aptamer SL1 as a potential novel therapeutic option for myeloma
por: Zhang, Yibin, et al.
Publicado: (2018)

Tyrosine Phosphorylation of Botulinum Neurotoxin Protease Domains
por: Toth, Stephen, et al.
Publicado: (2012)

Crystal structure of the SH3 domain of human Lyn non-receptor tyrosine kinase
por: Berndt, Sandra, et al.
Publicado: (2019)

Leptin Protein Expression and Promoter Methylation in Ovarian Cancer: A Strong Prognostic Value with Theranostic Promises
por: Assidi, Mourad, et al.
Publicado: (2021)

A novel mutation in the tyrosine kinase domain of ERBB2 in hepatocellular carcinoma
por: Bekaii-Saab, Tanios, et al.
Publicado: (2006)

Tyrosine kinase domain mutations in chronic myelogenous leukemia patients: Indian perspective
por: Ghosh, K
Publicado: (2022)

Crystal structure of the kinase domain of a receptor tyrosine kinase from a choanoflagellate, Monosiga brevicollis
por: Bajaj, Teena, et al.
Publicado: (2023)

Tyrosine kinase domain mutations of EGFR gene in head and neck squamous cell carcinoma
por: Vatte, Chittibabu, et al.
Publicado: (2017)

Prevalence of ApoB100 rs693 gene polymorphism in metabolic syndrome among female students at King Abdulaziz University
por: Alghamdi, Rana A., et al.
Publicado: (2021)

The Use of Bruton Tyrosine Kinase Inhibitors in Waldenström’s Macroglobulinemia
por: Khan, Abdullah Mohammad
Publicado: (2022)

Does Generic Cyclic Kinase Insert Domain of Receptor Tyrosine Kinase KIT Clone Its Native Homologue?
por: Ledoux, Julie, et al.
Publicado: (2022)

Tyrosine Kinases in Cancer
por: Blau, Olga, et al.
Publicado: (2015)

The FGF Receptor–1 Tyrosine Kinase Domain Regulates Myogenesis but Is Not Sufficient to Stimulate Proliferation
por: Kudla, Arthur J., et al.
Publicado: (1998)

Crystal Structure of the Sema-PSI Extracellular Domain of Human RON Receptor Tyrosine Kinase
por: Chao, Kinlin L., et al.
Publicado: (2012)

Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase
por: Reckel, Sina, et al.
Publicado: (2017)

Proteolytic cleavages in the extracellular domain of receptor tyrosine kinases by membrane-associated serine proteases
por: Chen, Li-Mei, et al.
Publicado: (2017)

X-Linked Agammaglobulinemia Case with TH Domain Missense Mutation in Bruton Tyrosine Kinase
por: Agrebi, Nourhen, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_995gs47laso6mm83594vgb9lva