Novel Sterically Crowded and Conformationally Constrained α-Aminophosphonates with a Near-Neutral pK(a) as Highly Accurate (31)P NMR pH Probes. Application to Subtle pH Gradients Determination in Dictyostelium discoideum Cells

In order to discover new (31)P NMR markers for probing subtle pH changes (<0.2 pH unit) in biological environments, fifteen new conformationally constrained or sterically hindered α-aminophosphonates derived from diethyl(2-methylpyrrolidin-2-yl)phosphonate were synthesized and tested for their pH...

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Autores principales:	Delehedde, Caroline, Culcasi, Marcel, Ricquebourg, Emilie, Cassien, Mathieu, Siri, Didier, Blaive, Bruno, Pietri, Sylvia, Thétiot-Laurent, Sophie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320275/ https://www.ncbi.nlm.nih.gov/pubmed/35889385 http://dx.doi.org/10.3390/molecules27144506