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Novel Sterically Crowded and Conformationally Constrained α-Aminophosphonates with a Near-Neutral pK(a) as Highly Accurate (31)P NMR pH Probes. Application to Subtle pH Gradients Determination in Dictyostelium discoideum Cells
In order to discover new (31)P NMR markers for probing subtle pH changes (<0.2 pH unit) in biological environments, fifteen new conformationally constrained or sterically hindered α-aminophosphonates derived from diethyl(2-methylpyrrolidin-2-yl)phosphonate were synthesized and tested for their pH...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320275/ https://www.ncbi.nlm.nih.gov/pubmed/35889385 http://dx.doi.org/10.3390/molecules27144506 |