Computer-Aided and AILDE Approaches to Design Novel 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors

4-Hydroxyphenylpyruvate dioxygenase (HPPD) is a pivotal enzyme in tocopherol and plastoquinone synthesis and a potential target for novel herbicides. Thirty-five pyridine derivatives were selected to establish a Topomer comparative molecular field analysis (Topomer CoMFA) model to obtain correlation...

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Detalles Bibliográficos
Autores principales: Shi, Juan, Gao, Shuang, Wang, Jia-Yu, Ye, Tong, Yue, Ming-Li, Fu, Ying, Ye, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320391/
https://www.ncbi.nlm.nih.gov/pubmed/35887168
http://dx.doi.org/10.3390/ijms23147822

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320391/
https://www.ncbi.nlm.nih.gov/pubmed/35887168
http://dx.doi.org/10.3390/ijms23147822

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