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Computer-Aided and AILDE Approaches to Design Novel 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors

4-Hydroxyphenylpyruvate dioxygenase (HPPD) is a pivotal enzyme in tocopherol and plastoquinone synthesis and a potential target for novel herbicides. Thirty-five pyridine derivatives were selected to establish a Topomer comparative molecular field analysis (Topomer CoMFA) model to obtain correlation...

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Detalles Bibliográficos
Autores principales:	Shi, Juan, Gao, Shuang, Wang, Jia-Yu, Ye, Tong, Yue, Ming-Li, Fu, Ying, Ye, Fei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320391/ https://www.ncbi.nlm.nih.gov/pubmed/35887168 http://dx.doi.org/10.3390/ijms23147822

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