Beyond Pathogenic RUNX1 Germline Variants: The Spectrum of Somatic Alterations in RUNX1-Familial Platelet Disorder with Predisposition to Hematologic Malignancies

SIMPLE SUMMARY: Pathogenic germline variants affecting RUNX1 are associated with qualitative and/or quantitative platelet defects, and predispose to hematologic malignancies. The latter manifests in approximately 44% of carriers and can occur from early childhood to late adulthood. In addition to th...

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Detalles Bibliográficos
Autores principales: Förster, Alisa, Decker, Melanie, Schlegelberger, Brigitte, Ripperger, Tim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320507/
https://www.ncbi.nlm.nih.gov/pubmed/35884491
http://dx.doi.org/10.3390/cancers14143431

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320507/
https://www.ncbi.nlm.nih.gov/pubmed/35884491
http://dx.doi.org/10.3390/cancers14143431

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