Effects of a Serine Protease Inhibitor N-p-Tosyl-L-phenylalanine Chloromethyl Ketone (TPCK) on Leishmania amazonensis and Leishmania infantum

Studies have previously demonstrated the importance of serine proteases in Leishmania. A well-known serine protease inhibitor, TPCK, was used in the present study to evaluate its in vitro and in vivo antileishmanial effects and determine its mechanism of action. Despite slight toxicity against mamma...

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Detalles Bibliográficos
Autores principales: Machado, Patrícia de A., Gomes, Pollyanna S., Carneiro, Monique P. D., Midlej, Victor, Coimbra, Elaine S., de Matos Guedes, Herbert L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320531/
https://www.ncbi.nlm.nih.gov/pubmed/35890269
http://dx.doi.org/10.3390/pharmaceutics14071373

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320531/
https://www.ncbi.nlm.nih.gov/pubmed/35890269
http://dx.doi.org/10.3390/pharmaceutics14071373

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