The Marine-Derived Macrolactone Mandelalide A Is an Indirect Activator of AMPK

The mandelalides are complex macrolactone natural products with distinct macrocycle motifs and a bioactivity profile that is heavily influenced by compound glycosylation. Mandelalides A and B are direct inhibitors of mitochondrial ATP synthase (complex V) and therefore more toxic to mammalian cells...

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Detalles Bibliográficos
Autores principales: Mattos, Daphne R., Wan, Xuemei, Serrill, Jeffrey D., Nguyen, Minh H., Humphreys, Ian R., Viollet, Benoit, Smith, Amos B., McPhail, Kerry L., Ishmael, Jane E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320534/
https://www.ncbi.nlm.nih.gov/pubmed/35877711
http://dx.doi.org/10.3390/md20070418

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320534/
https://www.ncbi.nlm.nih.gov/pubmed/35877711
http://dx.doi.org/10.3390/md20070418

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