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The Marine-Derived Macrolactone Mandelalide A Is an Indirect Activator of AMPK

The mandelalides are complex macrolactone natural products with distinct macrocycle motifs and a bioactivity profile that is heavily influenced by compound glycosylation. Mandelalides A and B are direct inhibitors of mitochondrial ATP synthase (complex V) and therefore more toxic to mammalian cells...

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Detalles Bibliográficos
Autores principales:	Mattos, Daphne R., Wan, Xuemei, Serrill, Jeffrey D., Nguyen, Minh H., Humphreys, Ian R., Viollet, Benoit, Smith, Amos B., McPhail, Kerry L., Ishmael, Jane E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320534/ https://www.ncbi.nlm.nih.gov/pubmed/35877711 http://dx.doi.org/10.3390/md20070418

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