Computational study on novel natural compound inhibitor targeting IDH1_R132H

Isocitrate dehydrogenases (IDH) catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. IDH1 mutation has been reported in various tumors especially Cholangiocarcinoma, while the IDH1_R132H is reported to be the most common mutation of IDH1. IDH1_R132H inhibitors are effective anti-c...

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Detalles Bibliográficos
Autores principales: Zhou, Baolin, Yang, Fang, Qin, Lei, Kuai, Jun, Yang, Lu, Zhang, Lanfang, Sun, Peisheng, Li, Guangpeng, Wang, Xinhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320544/
https://www.ncbi.nlm.nih.gov/pubmed/35802554
http://dx.doi.org/10.18632/aging.204162

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320544/
https://www.ncbi.nlm.nih.gov/pubmed/35802554
http://dx.doi.org/10.18632/aging.204162

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