Structure-Based Identification and Biological Characterization of New NAPRT Inhibitors

NAPRT, the rate-limiting enzyme of the Preiss–Handler NAD biosynthetic pathway, has emerged as a key biomarker for the clinical success of NAMPT inhibitors in cancer treatment. Previous studies found that high protein levels of NAPRT conferred resistance to NAMPT inhibition in several tumor types wh...

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Detalles Bibliográficos
Autores principales: Franco, Jorge, Piacente, Francesco, Walter, Melanie, Fratta, Simone, Ghanem, Moustafa, Benzi, Andrea, Caffa, Irene, Kurkin, Alexander V., Altieri, Andrea, Herr, Patrick, Martínez-Bailén, Macarena, Robina, Inmaculada, Bruzzone, Santina, Nencioni, Alessio, Del Rio, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320560/
https://www.ncbi.nlm.nih.gov/pubmed/35890155
http://dx.doi.org/10.3390/ph15070855

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320560/
https://www.ncbi.nlm.nih.gov/pubmed/35890155
http://dx.doi.org/10.3390/ph15070855

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