Synthesis, Biological Evaluation and Docking Studies of Ring-Opened Analogues of Ipomoeassin F

The plant-derived macrocyclic resin glycoside ipomoeassin F (Ipom-F) binds to Sec61α and significantly disrupts multiple aspects of Sec61-mediated protein biogenesis at the endoplasmic reticulum, ultimately leading to cell death. However, extensive assessment of Ipom-F as a molecular tool and a ther...

Descripción completa

Detalles Bibliográficos
Autores principales: O’Keefe, Sarah, Bhadra, Pratiti, Duah, Kwabena B., Zong, Guanghui, Tenay, Levise, Andrews, Lauren, Schneider, Hayden, Anderson, Ashley, Hu, Zhijian, Aljewari, Hazim S., Hall, Belinda S., Simmonds, Rachel E., Helms, Volkhard, High, Stephen, Shi, Wei Q.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320607/
https://www.ncbi.nlm.nih.gov/pubmed/35889292
http://dx.doi.org/10.3390/molecules27144419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320607/
https://www.ncbi.nlm.nih.gov/pubmed/35889292
http://dx.doi.org/10.3390/molecules27144419

Ejemplares similares