Cargando…

Synthesis, Biological Evaluation and Docking Studies of Ring-Opened Analogues of Ipomoeassin F

The plant-derived macrocyclic resin glycoside ipomoeassin F (Ipom-F) binds to Sec61α and significantly disrupts multiple aspects of Sec61-mediated protein biogenesis at the endoplasmic reticulum, ultimately leading to cell death. However, extensive assessment of Ipom-F as a molecular tool and a ther...

Descripción completa

Detalles Bibliográficos
Autores principales:	O’Keefe, Sarah, Bhadra, Pratiti, Duah, Kwabena B., Zong, Guanghui, Tenay, Levise, Andrews, Lauren, Schneider, Hayden, Anderson, Ashley, Hu, Zhijian, Aljewari, Hazim S., Hall, Belinda S., Simmonds, Rachel E., Helms, Volkhard, High, Stephen, Shi, Wei Q.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320607/ https://www.ncbi.nlm.nih.gov/pubmed/35889292 http://dx.doi.org/10.3390/molecules27144419

Ejemplares similares

Ring Expansion Leads to a More Potent Analogue of Ipomoeassin F
por: Zong, Guanghui, et al.
Publicado: (2020)

Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor
por: O’Keefe, Sarah, et al.
Publicado: (2021)

Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor
por: O'Keefe, Sarah, et al.
Publicado: (2021)

Ipomoeassin-F disrupts multiple aspects of secretory protein biogenesis
por: Roboti, Peristera, et al.
Publicado: (2021)

Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation
por: Zong, Guanghui, et al.
Publicado: (2019)

Molecular Modeling of Signal Peptide Recognition by Eukaryotic Sec Complexes
por: Bhadra, Pratiti, et al.
Publicado: (2021)

An alternative pathway for membrane protein biogenesis at the endoplasmic reticulum
por: O’Keefe, Sarah, et al.
Publicado: (2021)

How does Sec63 affect the conformation of Sec61 in yeast?
por: Bhadra, Pratiti, et al.
Publicado: (2021)

ER translocon inhibitor ipomoeassin F inhibits triple-negative breast cancer growth via blocking ER molecular chaperones
por: Tao, Shishi, et al.
Publicado: (2023)

Mycolactone enhances the Ca(2+) leak from endoplasmic reticulum by trapping Sec61 translocons in a Ca(2+) permeable state
por: Bhadra, Pratiti, et al.
Publicado: (2021)

Signal Peptide Features Determining the Substrate Specificities of Targeting and Translocation Components in Human ER Protein Import
por: Lang, Sven, et al.
Publicado: (2022)

Quantitative Proteomics and Differential Protein Abundance Analysis after Depletion of Putative mRNA Receptors in the ER Membrane of Human Cells Identifies Novel Aspects of mRNA Targeting to the ER
por: Bhadra, Pratiti, et al.
Publicado: (2021)

Proteomics Identifies Substrates and a Novel Component in hSnd2-Dependent ER Protein Targeting
por: Tirincsi, Andrea, et al.
Publicado: (2022)

Eeyarestatin Compounds Selectively Enhance Sec61-Mediated Ca(2+) Leakage from the Endoplasmic Reticulum
por: Gamayun, Igor, et al.
Publicado: (2019)

Microcystin-LR Removal from Water via Enzymatic Linearization and Ultrafiltration
por: Fionah, Abelline, et al.
Publicado: (2022)

Molecular docking analysis of curcumin analogues with COX-2
por: Sohilait, Mario Rowan, et al.
Publicado: (2017)

Molecular docking analysis of aspirin analogues with β-catenin
por: Selvaraj, Jayaraman, et al.
Publicado: (2020)

Phenylbutyrate rescues the transport defect of the Sec61α mutations V67G and T185A for renin
por: Sicking, Mark, et al.
Publicado: (2022)

Identifying transcription factor complexes and their roles
por: Will, Thorsten, et al.
Publicado: (2014)

Rewiring of the inferred protein interactome during blood development studied with the tool PPICompare
por: Will, Thorsten, et al.
Publicado: (2017)

Differential analysis of combinatorial protein complexes with CompleXChange
por: Will, Thorsten, et al.
Publicado: (2019)

Larvicidal activity of novel anthraquinone analogues and their molecular docking studies
por: Selvaraj, Keerthana, et al.
Publicado: (2021)

Quinazoline analogues as cytotoxic agents; QSAR, docking, and in silico studies
por: Emami, Leila, et al.
Publicado: (2021)

Molecular docking analysis of metformin analogues with GSK-3β
por: Rajagopal, Ponnu lakshmi, et al.
Publicado: (2022)

Molecular Docking of Cryptoconcatones to α-Tubulin and Related Pironetin Analogues
por: Vergoten, Gérard, et al.
Publicado: (2023)

Transferring functional annotations of membrane transporters on the basis of sequence similarity and sequence motifs
por: Barghash, Ahmad, et al.
Publicado: (2013)

TopControl: A Tool to Prioritize Candidate Disease-associated Genes based on Topological Network Features
por: Nazarieh, Maryam, et al.
Publicado: (2019)

Development of a less toxic dichloroacetate analogue by docking and descriptor analysis
por: Subramanian, Kannan, et al.
Publicado: (2010)

Quinoline based furanones and their nitrogen analogues: Docking, synthesis and biological evaluation
por: Khokra, Sukhbir Lal, et al.
Publicado: (2016)

Sevanol and Its Analogues: Chemical Synthesis, Biological Effects and Molecular Docking
por: Belozerova, Olga A., et al.
Publicado: (2020)

Molecular docking analysis of docetaxel analogues as duel lipocalin 2 inhibitors
por: Ponnulakshmi, Rajagopal, et al.
Publicado: (2020)

Characterizing the selectivity of ER α-glucosidase inhibitors
por: O’Keefe, Sarah, et al.
Publicado: (2019)

COX-2 structural analysis and docking studies with gallic acid structural analogues
por: Amaravani, M, et al.
Publicado: (2012)

Novel Penicillin Analogues as Potential Antimicrobial Agents; Design, Synthesis and Docking Studies
por: Ashraf, Zaman, et al.
Publicado: (2015)

3D-QSAR, docking and ADMET properties of aurone analogues as antimalarial agents
por: Hadni, Hanine, et al.
Publicado: (2020)

Molecular docking analysis of Enterotoxin I from Staphylococcus aureus with Nafcillin analogues
por: Selvaraj, Jayaraman, et al.
Publicado: (2020)

Synthesis, DFT Analyses, Antiproliferative Activity, and Molecular Docking Studies of Curcumin Analogues
por: Ahsan, Mohamed Jawed, et al.
Publicado: (2022)

Prediction of the burial status of transmembrane residues of helical membrane proteins
por: Park, Yungki, et al.
Publicado: (2007)

Composition of Overlapping Protein-Protein and Protein-Ligand Interfaces
por: Mohamed, Ruzianisra, et al.
Publicado: (2015)

Interfering with Bacterial Quorum Sensing
por: Reuter, Kerstin, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_8cqqon0t3vb7mu1p9a19erlgpo