Cargando…

Effects of Lipid Shape and Interactions on the Conformation, Dynamics, and Curvature of Ultrasound-Responsive Liposomes

We perform coarse-grained molecular dynamics simulations of bilayers composed of various lipids and cholesterol at their different ratios. Simulations show that cholesterol-lipid interactions restrict the lateral dynamics of bilayers but also promote bilayer curvature, indicating that these opposite...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Hwankyu, Moon, Hyungwon, Kim, Hyun-Ryoung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320727/ https://www.ncbi.nlm.nih.gov/pubmed/35890407 http://dx.doi.org/10.3390/pharmaceutics14071512

Ejemplares similares

Ultrasound-Responsive Liposomes for Targeted Drug Delivery Combined with Focused Ultrasound
por: Kim, Yoon-Seok, et al.
Publicado: (2022)

Evading Doxorubicin-Induced Systemic Immunosuppression Using Ultrasound-Responsive Liposomes Combined with Focused Ultrasound
por: Lee, Jeongjin, et al.
Publicado: (2022)

Amphiphilic nanoparticles generate curvature in lipid membranes and shape liposome–liposome interfaces
por: Lavagna, E., et al.
Publicado: (2021)

Molecular Simulations of PEGylated Biomolecules, Liposomes, and Nanoparticles for Drug Delivery Applications
por: Lee, Hwankyu
Publicado: (2020)

Phosphatidic Acid Accumulates at Areas of Curvature in Tubulated Lipid Bilayers and Liposomes
por: Bills, Broderick L., et al.
Publicado: (2022)

Formulation Optimization and In Vivo Proof-of-Concept Study of Thermosensitive Liposomes Balanced by Phospholipid, Elastin-Like Polypeptide, and Cholesterol
por: Park, Sun Min, et al.
Publicado: (2014)

Lipids with negative spontaneous curvature decrease the solubility of the cancer drug paclitaxel in liposomes
por: Steffes, Victoria, et al.
Publicado: (2023)

All-atom simulations and free-energy calculations of coiled-coil peptides with lipid bilayers: binding strength, structural transition, and effect on lipid dynamics
por: Woo, Sun Young, et al.
Publicado: (2016)

Conformal invariance of curvature perturbation
por: Gong, Jinn-Ouk, et al.
Publicado: (2011)

Structures, dynamics, and hydrogen-bond interactions of antifreeze proteins in TIP4P/Ice water and their dependence on force fields
por: Lee, Hwankyu
Publicado: (2018)

Conformal Differential Geometry: Q-Curvature and Conformal Holonomy
por: Baum, Helga, et al.
Publicado: (2010)

Drug delivery by sonosensitive liposome and microbubble with acoustic-lens attached ultrasound: an in vivo feasibility study in a murine melanoma model
por: Park, Jun Hong, et al.
Publicado: (2023)

Direct protein-lipid interactions shape the conformational landscape of secondary transporters
por: Martens, Chloe, et al.
Publicado: (2018)

Single Lipid Molecule Dynamics on Supported Lipid Bilayers with Membrane Curvature
por: Cheney, Philip P., et al.
Publicado: (2017)

The dynamics of shapes of vesicle membranes with time dependent spontaneous curvature
por: Barrio, R. A., et al.
Publicado: (2020)

Conformation and Lipid Interaction of the Fusion Peptide of the Paramyxovirus PIV5 in Anionic and Negative-Curvature Membranes from Solid-State NMR
por: Yao, Hongwei, et al.
Publicado: (2014)

Combination Therapy with Doxorubicin-Loaded Reduced Albumin Nanoparticles and Focused Ultrasound in Mouse Breast Cancer Xenografts
por: Kim, Daehyun, et al.
Publicado: (2020)

Molecular Modeling of Protein Corona Formation and Its Interactions with Nanoparticles and Cell Membranes for Nanomedicine Applications
por: Lee, Hwankyu
Publicado: (2021)

Lipids, curvature, and nano-medicine*
por: Mouritsen, Ole G
Publicado: (2011)

Existence of conformal metrics on spheres with prescribed Paneitz curvature
por: Ben-Ayed, M, et al.
Publicado: (2003)

Arf1 and Membrane Curvature Cooperate to Recruit Arfaptin2 to Liposomes
por: Ambroggio, Ernesto E., et al.
Publicado: (2013)

Multiscale Modeling of Dendrimers and Their Interactions with Bilayers and Polyelectrolytes
por: Lee, Hwankyu, et al.
Publicado: (2009)

Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter
por: Tang, Qingyu, et al.
Publicado: (2023)

Constant curvature modeling of abstract shape representation
por: Baker, Nicholas, et al.
Publicado: (2021)

Families of Conformally Covariant Differential Operators, Q-Curvature and Holography
por: Juhl, Andreas
Publicado: (2009)

Ezrin enrichment on curved membranes requires a specific conformation or interaction with a curvature-sensitive partner
por: Tsai, Feng-Ching, et al.
Publicado: (2018)

Cysteine-Encapsulated Liposome for Investigating Biomolecular Interactions at Lipid Membranes
por: Nguyen, Trang Thi Thuy, et al.
Publicado: (2022)

Conformational Dynamics and Stability of U-Shaped and S-Shaped Amyloid β Assemblies
por: Grasso, Gianvito, et al.
Publicado: (2018)

Haptic curvature contrast in raised lines and solid shapes
por: Wijntjes, Maarten W. A., et al.
Publicado: (2009)

Curvature effects and the shape of bunches in electron storage rings
por: Pellegrini, C, et al.
Publicado: (1967)

Curvature effects and the shape of bunches in electron-storage rings
por: Pellegrini, C, et al.
Publicado: (1968)

Gaussian Curvature Entropy for Curved Surface Shape Generation
por: Okano, Akihiro, et al.
Publicado: (2020)

Early response evaluation of doxorubicin-nanoparticle-microbubble therapy in orthotopic hepatocellular carcinoma rat model using contrast-enhanced ultrasound and intravoxel incoherent motion-diffusion MRI
por: Yang, Hyun Kyung, et al.
Publicado: (2022)

Raft Formation in Lipid Bilayers Coupled to Curvature
por: Sadeghi, Sina, et al.
Publicado: (2014)

Single-molecule conformational dynamics of viroporin ion channels regulated by lipid-protein interactions
por: Largo, Eneko, et al.
Publicado: (2021)

The effect of membrane curvature on the conformation of antimicrobial peptides: implications for binding and the mechanism of action
por: Chen, Rong, et al.
Publicado: (2011)

Encoding of Complexity, Shape, and Curvature by Macaque Infero-Temporal Neurons
por: Kayaert, Greet, et al.
Publicado: (2011)

Effects of the shape of curvature peaks on the size of primordial black holes
por: Escrivà, Albert, et al.
Publicado: (2021)

Corneal Curvature: the Influence of Corneal Accommodation and Biomechanics on Corneal Shape
por: Wallace, Henry B., et al.
Publicado: (2019)

Boundary curvature guided programmable shape-morphing kirigami sheets
por: Hong, Yaoye, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_sjacen8qtubsn3usap882oic9q