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Selective activation and down‐regulation of Trk receptors by neurotrophins in human neurons co‐expressing TrkB and TrkC

In the central nervous system, most neurons co‐express TrkB and TrkC, the tyrosine kinase receptors for brain‐derived neurotrophic factor (BDNF) and neurotrophin‐3 (NT3). As NT3 can also activate TrkB, it has been difficult to understand how NT3 and TrkC can exert unique roles in the assembly of neu...

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Detalles Bibliográficos
Autores principales: Ateaque, Sarah, Merkouris, Spyros, Wyatt, Sean, Allen, Nicholas D., Xie, Jia, DiStefano, Peter S., Lindsay, Ronald M., Barde, Yves‐Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321069/
https://www.ncbi.nlm.nih.gov/pubmed/35536742
http://dx.doi.org/10.1111/jnc.15617