Discovery of New 3,3-Diethylazetidine-2,4-dione Based Thiazoles as Nanomolar Human Neutrophil Elastase Inhibitors with Broad-Spectrum Antiproliferative Activity

A series of 3,3-diethylazetidine-2,4-dione based thiazoles 3a–3j were designed and synthesized as new human neutrophil elastase (HNE) inhibitors in nanomolar range. The representative compounds 3c, 3e, and 3h exhibit high HNE inhibitory activity with IC(50) values of 35.02–44.59 nM, with mixed mecha...

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Detalles Bibliográficos
Autores principales: Donarska, Beata, Świtalska, Marta, Wietrzyk, Joanna, Płaziński, Wojciech, Mizerska-Kowalska, Magdalena, Zdzisińska, Barbara, Łączkowski, Krzysztof Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321231/
https://www.ncbi.nlm.nih.gov/pubmed/35886913
http://dx.doi.org/10.3390/ijms23147566

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321231/
https://www.ncbi.nlm.nih.gov/pubmed/35886913
http://dx.doi.org/10.3390/ijms23147566

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