Computational and Experimental Evaluation of the Stability of a GLP-1-like Peptide in Ethanol–Water Mixtures

Aggregation resulting from the self-association of peptide molecules remains a major challenge during preformulation. Whereas certain organic solvents are known to promote aggregation, ethanol (EtOH) is capable of disrupting interactions between peptide molecules. It is unclear whether it is benefic...

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Detalles Bibliográficos
Autores principales: Lui, Lok Hin, Egbu, Raphael, Graver, Thomas, Williams, Gareth R., Brocchini, Steve, Velayudhan, Ajoy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321252/
https://www.ncbi.nlm.nih.gov/pubmed/35890357
http://dx.doi.org/10.3390/pharmaceutics14071462

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321252/
https://www.ncbi.nlm.nih.gov/pubmed/35890357
http://dx.doi.org/10.3390/pharmaceutics14071462

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