Malarial PI4K inhibitor induced diaphragmatic hernias in rat: Potential link with mammalian kinase inhibition

BACKGROUND: MMV390048 is an aminopyridine plasmodial PI4K inhibitor, selected as a Plasmodium blood‐stage schizonticide for a next generation of malaria treatments to overcome resistance to current therapies. MMV390048 showed an acceptable preclinical safety profile and progressed up to Phase 2a cli...

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Detalles Bibliográficos
Autores principales: Demarta‐Gatsi, Claudia, Donini, Cristina, Duffy, James, Sadler, Claire, Stewart, Jane, Barber, Jane A., Tornesi, Belen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321963/
https://www.ncbi.nlm.nih.gov/pubmed/35416431
http://dx.doi.org/10.1002/bdr2.2012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321963/
https://www.ncbi.nlm.nih.gov/pubmed/35416431
http://dx.doi.org/10.1002/bdr2.2012

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