Upregulation of Nrf2/HO-1 Signaling and Attenuation of Oxidative Stress, Inflammation, and Cell Death Mediate the Protective Effect of Apigenin against Cyclophosphamide Hepatotoxicity

Liver injury is among the adverse effects of the chemotherapeutic agent cyclophosphamide (CP). This study investigated the protective role of the flavone apigenin (API) against CP-induced liver damage, pointing to the involvement of Nrf2/HO-1 signaling. Rats were treated with API (20 and 40 mg/kg) f...

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Detalles Bibliográficos
Autores principales: Al-Amarat, Wesam, Abukhalil, Mohammad H., Alruhaimi, Reem S., Alqhtani, Haifa A., Aldawood, Nouf, Alfwuaires, Manal A., Althunibat, Osama Y., Aladaileh, Saleem H., Algefare, Abdulmohsen I., Alanezi, Abdulkareem A., AbouEl-ezz, Ali M., Ahmeda, Ahmad F., Mahmoud, Ayman M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322057/
https://www.ncbi.nlm.nih.gov/pubmed/35888772
http://dx.doi.org/10.3390/metabo12070648

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322057/
https://www.ncbi.nlm.nih.gov/pubmed/35888772
http://dx.doi.org/10.3390/metabo12070648

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