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Upregulation of Nrf2/HO-1 Signaling and Attenuation of Oxidative Stress, Inflammation, and Cell Death Mediate the Protective Effect of Apigenin against Cyclophosphamide Hepatotoxicity
Liver injury is among the adverse effects of the chemotherapeutic agent cyclophosphamide (CP). This study investigated the protective role of the flavone apigenin (API) against CP-induced liver damage, pointing to the involvement of Nrf2/HO-1 signaling. Rats were treated with API (20 and 40 mg/kg) f...
Autores principales: | Al-Amarat, Wesam, Abukhalil, Mohammad H., Alruhaimi, Reem S., Alqhtani, Haifa A., Aldawood, Nouf, Alfwuaires, Manal A., Althunibat, Osama Y., Aladaileh, Saleem H., Algefare, Abdulmohsen I., Alanezi, Abdulkareem A., AbouEl-ezz, Ali M., Ahmeda, Ahmad F., Mahmoud, Ayman M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322057/ https://www.ncbi.nlm.nih.gov/pubmed/35888772 http://dx.doi.org/10.3390/metabo12070648 |
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