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Bioactive polyphenols in kinkéliba tea (Combretum micranthum) and their glucose-lowering activities

Herbal tea kinkéliba prepared from the leaves of Combretum micranthum has been widely consumed in West African countries for its flavor, nutritional and medicinal properties. Under bio-guided screening, the kinkéliba leaves were chemically investigated using various chromatographic and spectrometric...

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Detalles Bibliográficos
Autores principales: Welch, Cara, Zhen, Jing, Bassène, Emmanuel, Raskin, Ilya, Simon, James Edward, Wu, Qingli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taiwan Food and Drug Administration 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322244/
https://www.ncbi.nlm.nih.gov/pubmed/29567217
http://dx.doi.org/10.1016/j.jfda.2017.05.009
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author Welch, Cara
Zhen, Jing
Bassène, Emmanuel
Raskin, Ilya
Simon, James Edward
Wu, Qingli
author_facet Welch, Cara
Zhen, Jing
Bassène, Emmanuel
Raskin, Ilya
Simon, James Edward
Wu, Qingli
author_sort Welch, Cara
collection PubMed
description Herbal tea kinkéliba prepared from the leaves of Combretum micranthum has been widely consumed in West African countries for its flavor, nutritional and medicinal properties. Under bio-guided screening, the kinkéliba leaves were chemically investigated using various chromatographic and spectrometric methods that led to the identification of thirteen different flavonoid compounds. Further biological tests illustrated that the identified compounds may have synergistic effects to decrease the expression of phosphoenolpyruvate carboxykinase (PEPCK) mRNA and glucose production in an H4IIE hepatoma cell line, indicating its potential use for insulin-resistant diabetes treatment. Further in vivo study on C57BL/6J mice indicates that kinkéliba can lower plasma glucose levels in a dose-dependent manner without significant weight loss and toxicity. The ethyl acetate extract in rich of flavonoids could also increase the glucose tolerance (GT) after seven weeks' administrations. Both in vitro and in vivo experiments support a potential new application of kinkeliba leaves as an anti-diabetes agent.
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spelling pubmed-93222442022-08-09 Bioactive polyphenols in kinkéliba tea (Combretum micranthum) and their glucose-lowering activities Welch, Cara Zhen, Jing Bassène, Emmanuel Raskin, Ilya Simon, James Edward Wu, Qingli J Food Drug Anal Original Article Herbal tea kinkéliba prepared from the leaves of Combretum micranthum has been widely consumed in West African countries for its flavor, nutritional and medicinal properties. Under bio-guided screening, the kinkéliba leaves were chemically investigated using various chromatographic and spectrometric methods that led to the identification of thirteen different flavonoid compounds. Further biological tests illustrated that the identified compounds may have synergistic effects to decrease the expression of phosphoenolpyruvate carboxykinase (PEPCK) mRNA and glucose production in an H4IIE hepatoma cell line, indicating its potential use for insulin-resistant diabetes treatment. Further in vivo study on C57BL/6J mice indicates that kinkéliba can lower plasma glucose levels in a dose-dependent manner without significant weight loss and toxicity. The ethyl acetate extract in rich of flavonoids could also increase the glucose tolerance (GT) after seven weeks' administrations. Both in vitro and in vivo experiments support a potential new application of kinkeliba leaves as an anti-diabetes agent. Taiwan Food and Drug Administration 2017-06-13 /pmc/articles/PMC9322244/ /pubmed/29567217 http://dx.doi.org/10.1016/j.jfda.2017.05.009 Text en © 2018 Taiwan Food and Drug Administration https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Original Article
Welch, Cara
Zhen, Jing
Bassène, Emmanuel
Raskin, Ilya
Simon, James Edward
Wu, Qingli
Bioactive polyphenols in kinkéliba tea (Combretum micranthum) and their glucose-lowering activities
title Bioactive polyphenols in kinkéliba tea (Combretum micranthum) and their glucose-lowering activities
title_full Bioactive polyphenols in kinkéliba tea (Combretum micranthum) and their glucose-lowering activities
title_fullStr Bioactive polyphenols in kinkéliba tea (Combretum micranthum) and their glucose-lowering activities
title_full_unstemmed Bioactive polyphenols in kinkéliba tea (Combretum micranthum) and their glucose-lowering activities
title_short Bioactive polyphenols in kinkéliba tea (Combretum micranthum) and their glucose-lowering activities
title_sort bioactive polyphenols in kinkéliba tea (combretum micranthum) and their glucose-lowering activities
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322244/
https://www.ncbi.nlm.nih.gov/pubmed/29567217
http://dx.doi.org/10.1016/j.jfda.2017.05.009
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