Evaluation of an icIEF‐MS system for comparable charge variant analysis of biotherapeutics with rapid peak identification by mass spectrometry

Protein therapeutics are usually produced in heterogeneous forms during bioproduction and bioprocessing. Heterogeneity results from post‐translational modifications that can yield charge variants and require characterization throughout product development and manufacturing. Isoelectric focusing (IEF...

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Detalles Bibliográficos
Autores principales: He, Xiaoping, ElNaggar, Mariam, Ostrowski, Maggie A., Guttman, Andras, Gentalen, Erik, Sperry, Justin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Proteins, Proteomics and 2d
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322286/
https://www.ncbi.nlm.nih.gov/pubmed/35286725
http://dx.doi.org/10.1002/elps.202100295

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322286/
https://www.ncbi.nlm.nih.gov/pubmed/35286725
http://dx.doi.org/10.1002/elps.202100295

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