Predictiveness of the Human-CYP3A4-Transgenic Mouse Model (Cyp3aXAV) for Human Drug Exposure of CYP3A4-Metabolized Drugs

The extrapolation of drug exposure between species remains a challenging step in drug development, contributing to the low success rate of drug approval. As a consequence, extrapolation of toxicology from animal models to humans to evaluate safe, first-in-human (FIH) doses requires high safety margi...

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Detalles Bibliográficos
Autores principales: Damoiseaux, David, Li, Wenlong, Martínez-Chávez, Alejandra, Beijnen, Jos H., Schinkel, Alfred H., Huitema, Alwin D. R., Dorlo, Thomas P. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322370/
https://www.ncbi.nlm.nih.gov/pubmed/35890158
http://dx.doi.org/10.3390/ph15070860

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322370/
https://www.ncbi.nlm.nih.gov/pubmed/35890158
http://dx.doi.org/10.3390/ph15070860

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