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Dawn and dusk peaks of outer segment phagocytosis, and visual cycle function require Rab28
RAB28 is a farnesylated, ciliary G‐protein. Patient variants in RAB28 are causative of autosomal recessive cone‐rod dystrophy (CRD), an inherited human blindness. In rodent and zebrafish models, the absence of Rab28 results in diminished dawn, photoreceptor, outer segment phagocytosis (OSP). Here, w...
Autores principales: | Moran, Ailís L., Carter, Stephen P., Kaylor, Joanna J., Jiang, Zhichun, Broekman, Sanne, Dillon, Eugene T., Gómez Sánchez, Alicia, Minhas, Sajal K., van Wijk, Erwin, Radu, Roxana A., Travis, Gabriel H., Carey, Michelle, Blacque, Oliver E., Kennedy, Breandán N. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322422/ https://www.ncbi.nlm.nih.gov/pubmed/35471581 http://dx.doi.org/10.1096/fj.202101897R |
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