Structure‐Based Evolution of G Protein‐Biased μ‐Opioid Receptor Agonists

The μ‐opioid receptor (μOR) is the major target for opioid analgesics. Activation of μOR initiates signaling through G protein pathways as well as through β‐arrestin recruitment. μOR agonists that are biased towards G protein signaling pathways demonstrate diminished side effects. PZM21, discovered...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Haoqing, Hetzer, Florian, Huang, Weijiao, Qu, Qianhui, Meyerowitz, Justin, Kaindl, Jonas, Hübner, Harald, Skiniotis, Georgios, Kobilka, Brian K., Gmeiner, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322534/
https://www.ncbi.nlm.nih.gov/pubmed/35385593
http://dx.doi.org/10.1002/anie.202200269

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322534/
https://www.ncbi.nlm.nih.gov/pubmed/35385593
http://dx.doi.org/10.1002/anie.202200269

Ejemplares similares