O-Glycan-Dependent Interaction between MUC1 Glycopeptide and MY.1E12 Antibody by NMR, Molecular Dynamics and Docking Simulations

Anti-mucin1 (MUC1) antibodies have been widely used for breast cancer diagnosis and treatment. This is based on the fact that MUC1 undergoes aberrant glycosylation upon cancer progression, and anti-MUC1 antibodies differentiate changes in glycan structure. MY.1E12 is a promising anti-MUC1 antibody w...

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Detalles Bibliográficos
Autores principales: Kokubu, Ryoka, Ohno, Shiho, Kuratani, Hirohide, Takahashi, Yuka, Manabe, Noriyoshi, Shimizu, Hiroki, Chiba, Yasunori, Denda-Nagai, Kaori, Tsuiji, Makoto, Irimura, Tatsuro, Yamaguchi, Yoshiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322718/
https://www.ncbi.nlm.nih.gov/pubmed/35887202
http://dx.doi.org/10.3390/ijms23147855

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322718/
https://www.ncbi.nlm.nih.gov/pubmed/35887202
http://dx.doi.org/10.3390/ijms23147855

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