Cargando…

Drug Discovery Using Evolutionary Similarities in Chemical Binding to Inhibit Patient-Derived Hepatocellular Carcinoma

Drug resistance causes therapeutic failure in refractory cancer. Cancer drug resistance stems from various factors, such as patient heterogeneity and genetic alterations in somatic cancer cells, including those from identical tissues. Generally, resistance is intrinsic for cancers; however, cancer r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lim, Jin Hong, Park, Keunwan, Choi, Kyung Hwa, Kim, Chan Wung, Lee, Jae Ha, Weicker, Raymond, Pan, Cheol-Ho, Kim, Seok-Mo, Park, Ki Cheong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322808/ https://www.ncbi.nlm.nih.gov/pubmed/35887321 http://dx.doi.org/10.3390/ijms23147971

Ejemplares similares

Potential Therapeutic Agents against Paclitaxel—And Sorafenib-Resistant Papillary Thyroid Carcinoma
por: Kim, Seok-Mo, et al.
Publicado: (2022)

Discovery of New Anti-Cancer Agents against Patient-Derived Sorafenib-Resistant Papillary Thyroid Cancer
por: Kim, Yuna, et al.
Publicado: (2023)

Machine learning-based chemical binding similarity using evolutionary relationships of target genes
por: Park, Keunwan, et al.
Publicado: (2019)

Identification of Tyrosinase Inhibitors and Their Structure-Activity Relationships via Evolutionary Chemical Binding Similarity and Structure-Based Methods
por: Durai, Prasannavenkatesh, et al.
Publicado: (2021)

Evolutionary chemical binding similarity approach integrated with 3D-QSAR method for effective virtual screening
por: Durai, Prasannavenkatesh, et al.
Publicado: (2020)

Iterative machine learning-based chemical similarity search to identify novel chemical inhibitors
por: Durai, Prasannavenkatesh, et al.
Publicado: (2023)

Discovery of Pharmaceutical Composition for Prevention and Treatment in Patient-Derived Metastatic Medullary Thyroid Carcinoma Model
por: Yun, Hyeok-Jun, et al.
Publicado: (2022)

Patient-Derived, Drug-Resistant Colon Cancer Cells Evade Chemotherapeutic Drug Effects via the Induction of Epithelial-Mesenchymal Transition-Mediated Angiogenesis
por: Lim, Jin Hong, et al.
Publicado: (2020)

Systemic evolutionary chemical space exploration for drug discovery
por: Lu, Chong, et al.
Publicado: (2022)

Drug-drug relationship based on target information: application to drug target identification
por: Park, Keunwan, et al.
Publicado: (2011)

Modeling allosteric signal propagation using protein structure networks
por: Park, Keunwan, et al.
Publicado: (2011)

Impact of Age-Related Genetic Differences on the Therapeutic Outcome of Papillary Thyroid Cancer
por: Kim, Seok-Mo, et al.
Publicado: (2020)

Molecular and Metabolic Phenotyping of Hepatocellular Carcinoma for Biomarker Discovery: A Meta-Analysis
por: Anh, Nguyen Hoang, et al.
Publicado: (2023)

Exploring chemical space for lead identification by propagating on chemical similarity network
por: Yi, Jungseob, et al.
Publicado: (2023)

The Effects of Hazardous Chemical Exposure on Cardiovascular Disease in Chemical Products Manufacturing Workers
por: Kim, Ki-Woong, et al.
Publicado: (2012)

Interaction network among functional drug groups
por: Lee, Minho, et al.
Publicado: (2013)

Three-Dimensional Evaluation of Similarity of Right and Left Knee Joints
por: Jang, Ki-Mo, et al.
Publicado: (2017)

Evolutionary chemical space exploration for functional materials: computational organic semiconductor discovery
por: Cheng, Chi Y., et al.
Publicado: (2020)

Potent and Selective Inhibition of CYP1A2 Enzyme by Obtusifolin and Its Chemopreventive Effects
por: Park, Eun-Ji, et al.
Publicado: (2022)

Computer-aided discovery of connected metal-organic frameworks
por: Kwon, Ohmin, et al.
Publicado: (2019)

An evolutionary algorithm for the discovery of porous organic cages
por: Berardo, Enrico, et al.
Publicado: (2018)

Hepatocellular carcinoma with characteristic mucin production: a case report
por: Lee, Kyung Hwa, et al.
Publicado: (2009)

Anti-cancer Effects of HNHA and Lenvatinib by the Suppression of EMT-Mediated Drug Resistance in Cancer Stem Cells()()
por: Lee, Yong Sang, et al.
Publicado: (2018)

SoLAT (Sorafenib Lenvatinib alternating treatment): a new treatment protocol with alternating Sorafenib and Lenvatinib for refractory thyroid Cancer
por: Kim, Soo Young, et al.
Publicado: (2018)

Hypokalemic periodic paralysis; two different genes responsible for similar clinical manifestations
por: Kim, Hunmin, et al.
Publicado: (2011)

Hepatocellular carcinoma-targeted drug discovery through image-based phenotypic screening in co-cultures of HCC cells with hepatocytes
por: Jang, Jae-Woo, et al.
Publicado: (2016)

NPF activates a specific NPF receptor and regulates food intake in Pacific abalone Haliotis discus hannai
por: Kim, Kyeong Seop, et al.
Publicado: (2021)

Similar Evolutionary Trajectories for Retrotransposon Accumulation in Mammals
por: Buckley, Reuben M., et al.
Publicado: (2017)

Proteomic similarity of the Littorinid snails in the evolutionary context
por: Maltseva, Arina L., et al.
Publicado: (2020)

PMCA inhibition reverses drug resistance in clinically refractory cancer patient-derived models
por: Park, Ki Cheong, et al.
Publicado: (2023)

The Overexpression of CCAR1 in Hepatocellular Carcinoma Associates with Poor Prognosis
por: Ha, Sang Yun, et al.
Publicado: (2016)

Potential anti-cancer effect of N-hydroxy-7-(2-naphthylthio) heptanomide (HNHA), a novel histone deacetylase inhibitor, for the treatment of thyroid cancer
por: Kim, Seok-Mo, et al.
Publicado: (2015)

Structure-Based Rational Design of a Toll-like Receptor 4 (TLR4) Decoy Receptor with High Binding Affinity for a Target Protein
por: Han, Jieun, et al.
Publicado: (2012)

Effect of Next-Generation Exome Sequencing Depth for Discovery of Diagnostic Variants
por: Kim, Kyung, et al.
Publicado: (2015)

Multiple tachykinins and their receptors characterized in the gastropod mollusk Pacific abalone: Expression, signaling cascades, and potential role in regulating lipid metabolism
por: Lee, Seungheon, et al.
Publicado: (2022)

The Role of Spinal Dopaminergic Transmission in the Analgesic Effect of Nefopam on Rat Inflammatory Pain
por: Kim, Do Yun, et al.
Publicado: (2016)

Similarity and Diversity in Chemical Design
por: Schlick, Tamar
Publicado: (2010)

Computational discovery of molecular C(60) encapsulants with an evolutionary algorithm
por: Miklitz, Marcin, et al.
Publicado: (2020)

Characteristics of the similarity index in a Korean medical journal
por: Chung, Seunghyun, et al.
Publicado: (2017)

Induction of Apoptosis by Coptisine in Hep3B Hepatocellular Carcinoma Cells through Activation of the ROS-Mediated JNK Signaling Pathway
por: Kim, So Young, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_l1hniqo6pdpdhdrg2hqaqi7qnn