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The Future of Tissue-Targeted Lipid Nanoparticle-Mediated Nucleic Acid Delivery

The earliest example of in vivo expression of exogenous mRNA is by direct intramuscular injection in mice without the aid of a delivery vehicle. The current state of the art for therapeutic nucleic acid delivery is lipid nanoparticles (LNP), which are composed of cholesterol, a helper lipid, a PEGyl...

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Detalles Bibliográficos
Autores principales: Kularatne, Ruvanthi N., Crist, Rachael M., Stern, Stephan T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322927/
https://www.ncbi.nlm.nih.gov/pubmed/35890195
http://dx.doi.org/10.3390/ph15070897