HDAC Inhibition Regulates Cardiac Function by Increasing Myofilament Calcium Sensitivity and Decreasing Diastolic Tension

We recently established a large animal model that recapitulates key clinical features of heart failure with preserved ejection fraction (HFpEF) and tested the effects of the pan-HDAC inhibitor suberoylanilide hydroxamic acid (SAHA). SAHA reversed and prevented the development of cardiopulmonary impa...

Descripción completa

Detalles Bibliográficos
Autores principales: Eaton, Deborah M., Martin, Thomas G., Kasa, Michael, Djalinac, Natasa, Ljubojevic-Holzer, Senka, Von Lewinski, Dirk, Pöttler, Maria, Kampaengsri, Theerachat, Krumphuber, Andreas, Scharer, Katharina, Maechler, Heinrich, Zirlik, Andreas, McKinsey, Timothy A., Kirk, Jonathan A., Houser, Steven R., Rainer, Peter P., Wallner, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323146/
https://www.ncbi.nlm.nih.gov/pubmed/35890404
http://dx.doi.org/10.3390/pharmaceutics14071509

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323146/
https://www.ncbi.nlm.nih.gov/pubmed/35890404
http://dx.doi.org/10.3390/pharmaceutics14071509

Ejemplares similares