Cargando…

HDAC Inhibition Regulates Cardiac Function by Increasing Myofilament Calcium Sensitivity and Decreasing Diastolic Tension

We recently established a large animal model that recapitulates key clinical features of heart failure with preserved ejection fraction (HFpEF) and tested the effects of the pan-HDAC inhibitor suberoylanilide hydroxamic acid (SAHA). SAHA reversed and prevented the development of cardiopulmonary impa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Eaton, Deborah M., Martin, Thomas G., Kasa, Michael, Djalinac, Natasa, Ljubojevic-Holzer, Senka, Von Lewinski, Dirk, Pöttler, Maria, Kampaengsri, Theerachat, Krumphuber, Andreas, Scharer, Katharina, Maechler, Heinrich, Zirlik, Andreas, McKinsey, Timothy A., Kirk, Jonathan A., Houser, Steven R., Rainer, Peter P., Wallner, Markus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323146/ https://www.ncbi.nlm.nih.gov/pubmed/35890404 http://dx.doi.org/10.3390/pharmaceutics14071509

Ejemplares similares

Functional remodelling of perinuclear mitochondria alters nucleoplasmic Ca(2+) signalling in heart failure
por: Voglhuber, Julia, et al.
Publicado: (2022)

miR-1183 Is a Key Marker of Remodeling upon Stretch and Tachycardia in Human Myocardium
por: Djalinac, Natasa, et al.
Publicado: (2022)

Nuclear Calcium in Cardiac (Patho)Physiology: Small Compartment, Big Impact
por: Kiessling, Mara, et al.
Publicado: (2023)

Cellular Heterogeneity of the Heart
por: Anto Michel, Nathaly, et al.
Publicado: (2022)

β-Adrenergic Receptor Stimulation Maintains NCX-CaMKII Axis and Prevents Overactivation of IL6R-Signaling in Cardiomyocytes upon Increased Workload
por: Matzer, Ingrid, et al.
Publicado: (2022)

Diastolic myofilament dysfunction in the failing human heart
por: van der Velden, Jolanda
Publicado: (2011)

The role of stretch, tachycardia and sodium‐calcium exchanger in induction of early cardiac remodelling
por: Djalinac, Natasa, et al.
Publicado: (2020)

HDAC6 modulates myofibril stiffness and diastolic function of the heart
por: Lin, Ying-Hsi, et al.
Publicado: (2022)

Loss of autophagy protein ATG5 impairs cardiac capacity in mice and humans through diminishing mitochondrial abundance and disrupting Ca(2+) cycling
por: Ljubojević-Holzer, Senka, et al.
Publicado: (2021)

Boosting the Exhausted Vasculature—SIRT3 (to the) Rescue
por: Ljubojevic-Holzer, Senka, et al.
Publicado: (2023)

CaMKII and PKA-dependent phosphorylation co-regulate nuclear localization of HDAC4 in adult cardiomyocytes
por: Helmstadter, Kathryn G., et al.
Publicado: (2021)

Echocardiographic Strain Analysis for the Early Detection of Left Ventricular Systolic/Diastolic Dysfunction and Dyssynchrony in a Mouse Model of Physiological Aging
por: de Lucia, Claudio, et al.
Publicado: (2019)

CaMKIIδC Drives Early Adaptive Ca(2+) Change and Late Eccentric Cardiac Hypertrophy
por: Ljubojevic-Holzer, Senka, et al.
Publicado: (2020)

The Myofilament Lattice: Studies on Isolated Fibers : III. The effect of myofilament spacing upon tension
por: April, Ernest W., et al.
Publicado: (1973)

Increased myofilament Ca(2+) sensitivity and diastolic dysfunction as early consequences of Mybpc3 mutation in heterozygous knock-in mice
por: Fraysse, Bodvaël, et al.
Publicado: (2012)

Diabetic Cardiomyopathy: Current and Future Therapies. Beyond Glycemic Control
por: Borghetti, Giulia, et al.
Publicado: (2018)

HDAC11 inhibition triggers bimodal thermogenic pathways to circumvent adipocyte catecholamine resistance
por: Robinson, Emma L., et al.
Publicado: (2023)

HDAC11 inhibition triggers bimodal thermogenic pathways to circumvent adipocyte catecholamine resistance
por: Robinson, Emma L., et al.
Publicado: (2023)

A NOTE ON THE STRUCTURE OF CRAYFISH MYOFILAMENTS
por: Peterson, R. Price
Publicado: (1963)

Myofilament function and body mass index
por: Bening, Constanze, et al.
Publicado: (2017)

Dystrophic cardiomyopathy: role of the cardiac myofilaments
por: George, Thomas G., et al.
Publicado: (2023)

Targeting Cardiovascular Risk Factors Through Dietary Adaptations and Caloric Restriction Mimetics
por: Voglhuber, Julia, et al.
Publicado: (2021)

REVERSIBLE DISAGGREGATION OF MYOFILAMENTS IN VERTEBRATE SMOOTH MUSCLE
por: Fay, Fredric S., et al.
Publicado: (1973)

Binge Alcohol Exposure in Adolescence Impairs Normal Heart Growth
por: Ai, Lizhuo, et al.
Publicado: (2020)

Value: The Four Cornerstones of Corporate Finance
por: Company, McKinsey
Publicado: (2010)

Treatment and Prevention of Histoplasmosis in Adults Living with HIV
por: McKinsey, David S.
Publicado: (2021)

MYOFILAMENTS IN SMOOTH MUSCLE OF GUINEA PIG'S TAENIA COLI
por: Nonomura, Yoshiaki
Publicado: (1968)

Leucine Supplementation Improves Diastolic Function in HFpEF by HDAC4 Inhibition
por: Alves, Paula Ketilly Nascimento, et al.
Publicado: (2023)

Effects of Short Term Adiponectin Receptor Agonism on Cardiac Function and Energetics in Diabetic db/db Mice
por: Tarkhnishvili, Aleksandre, et al.
Publicado: (2022)

THE MYOFILAMENT ARRANGEMENT IN THE FEMORAL MUSCLE OF THE COCKROACH, LEUCOPHAEA MADERAE FABRICIUS
por: Hagopian, Martin
Publicado: (1966)

Impact of anesthesia and storage on posttranslational modifications of cardiac myofilament proteins
por: Utter, Megan S, et al.
Publicado: (2015)

Myofilament Calcium Sensitivity: Consequences of the Effective Concentration of Troponin I
por: Siddiqui, Jalal K., et al.
Publicado: (2016)

Nebivolol Desensitizes Myofilaments of a Hypertrophic Cardiomyopathy Mouse Model
por: Stücker, Sabrina, et al.
Publicado: (2017)

Regulation of Myofilament Contractile Function in Human Donor and Failing Hearts
por: McDonald, Kerry S., et al.
Publicado: (2020)

Inorganic phosphate accelerates cardiac myofilament relaxation in response to lengthening
por: Wakefield, Jane I., et al.
Publicado: (2022)

Introduction to the theory of games
por: McKinsey, John C C
Publicado: (1952)

Strategies to improve HIV treatment adherence in developed countries: clinical management at the individual level
por: Enriquez, Maithe, et al.
Publicado: (2011)

Arcanobacterium Brain Abscesses, Subdural Empyema, and Bacteremia Complicating Epstein-Barr Virus Mononucleosis
por: Poplin, Victoria, et al.
Publicado: (2018)

Water and electrolyte content of the myofilament phase in the chemically skinned barnacle fiber
Publicado: (1980)

An Integrated Strategy to Study Muscle Development and Myofilament Structure in Caenorhabditis elegans
por: Meissner, Barbara, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_4vf661peeuhbtvomodfa14gjgr