Internal Introns Promote Backsplicing to Generate Circular RNAs from Spinal Muscular Atrophy Gene

Human survival motor neuron 1 (SMN1) codes for SMN, an essential housekeeping protein involved in most aspects of RNA metabolism. Deletions or mutations of SMN1 lead to spinal muscular atrophy (SMA), a devastating neurodegenerative disease linked to a high rate of infant mortality. SMN2, a near iden...

Descripción completa

Detalles Bibliográficos
Autores principales: Luo, Diou, Singh, Natalia Nikolaevna, Singh, Ravindra Narayan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323214/
https://www.ncbi.nlm.nih.gov/pubmed/35885927
http://dx.doi.org/10.3390/genes13071145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323214/
https://www.ncbi.nlm.nih.gov/pubmed/35885927
http://dx.doi.org/10.3390/genes13071145

Ejemplares similares