Downstream Processing of Itraconazole:HPMCAS Amorphous Solid Dispersion: From Hot-Melt Extrudate to Tablet Using a Quality by Design Approach

The downstream processing of hot-melt extruded amorphous solid dispersions (ASDs) into tablets is challenging due to the low tabletability of milled ASDs. Typically, the extrudate strand is sized before milling, as the strand cannot be fed directly into the milling system. At the lab scale, the stra...

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Detalles Bibliográficos
Autores principales: Mishra, Saurabh M, Richter, Margarethe, Mejia, Luis, Sauer, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323274/
https://www.ncbi.nlm.nih.gov/pubmed/35890324
http://dx.doi.org/10.3390/pharmaceutics14071429

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323274/
https://www.ncbi.nlm.nih.gov/pubmed/35890324
http://dx.doi.org/10.3390/pharmaceutics14071429

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