The Inhibitory Potential of 2′-dihalo Ribonucleotides against HCV: Molecular Docking, Molecular Simulations, MM-BPSA, and DFT Studies

Sofosbuvir is the first approved direct-acting antiviral (DAA) agent that inhibits the HCV NS5B polymerase, resulting in chain termination. The molecular models of the 2′-dihalo ribonucleotides used were based on experimental biological studies of HCV polymerase inhibitors. They were modeled within...

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Detalles Bibliográficos
Autores principales: Khalil, Ahmed, El-Khouly, Amany S., Elkaeed, Eslam B., Eissa, Ibrahim H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323285/
https://www.ncbi.nlm.nih.gov/pubmed/35889402
http://dx.doi.org/10.3390/molecules27144530

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323285/
https://www.ncbi.nlm.nih.gov/pubmed/35889402
http://dx.doi.org/10.3390/molecules27144530

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