Chaperone-Mediated Autophagy in Neurodegenerative Diseases: Molecular Mechanisms and Pharmacological Opportunities

Chaperone-mediated autophagy (CMA) is a protein degradation mechanism through lysosomes. By targeting the KFERQ motif of the substrate, CMA is responsible for the degradation of about 30% of cytosolic proteins, including a series of proteins associated with neurodegenerative diseases (NDs). The fact...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Yi-Ting, Lu, Jia-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323300/
https://www.ncbi.nlm.nih.gov/pubmed/35883693
http://dx.doi.org/10.3390/cells11142250

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323300/
https://www.ncbi.nlm.nih.gov/pubmed/35883693
http://dx.doi.org/10.3390/cells11142250

Ejemplares similares