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Inflammation-Driven Regulation of PD-L1 and PD-L2, and Their Cross-Interactions with Protective Soluble TNFα Receptors in Human Triple-Negative Breast Cancer

SIMPLE SUMMARY: Immune checkpoint blockades (ICBs) to PD-L1 have led to major breakthroughs in cancer therapy, but in triple-negative breast cancer (TNBC) success rates are rather limited. Following studies suggesting that chronic inflammation may limit ICB efficacy, we found that pro-inflammatory c...

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Detalles Bibliográficos
Autores principales: Baram, Tamir, Oren, Nino, Erlichman, Nofar, Meshel, Tsipi, Ben-Baruch, Adit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323351/
https://www.ncbi.nlm.nih.gov/pubmed/35884574
http://dx.doi.org/10.3390/cancers14143513